Toshio Fujishita

Structure of the HIV-1 integrase catalytic domain complexed with an inhibitor: A platform for antiviral drug design

Yehuda Goldgur, Robert Craigie, Gerson H. Cohen et al. · Proceedings of the National Academy of Sciences · 1999 · 494 citations

Life Sciences, Biochemistry, Molecular Biology +16

Enzymology of a carbonyl reduction clearance pathway for the HIV integrase inhibitor, S-1360: role of human liver cytosolic aldo-keto reductases

M. Jane Cox Rosemond, Lisa St. John‐Williams, Toshiro Yamaguchi et al. · Chemico-Biological Interactions · 2004 · 91 citations

Life Sciences, Biochemistry, Molecular Biology +15

Novel Angiotensin II Receptor Antagonists. Design, Synthesis, and in Vitro Evaluation of Dibenzo[a,d]cycloheptene and Dibenzo[b,f]oxepin Derivatives. Searching for Bioisosteres of Biphenyltetrazole Using a Three-Dimensional Search Technique

Ryuichi Kiyama, Tsunetoshi Honma, Kunio Hayashi et al. · Journal of Medicinal Chemistry · 1995 · 55 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Secondary mutations in viruses resistant to HIV-1 integrase inhibitors that restore viral infectivity and replication kinetics

Koichiro Nakahara, Chiaki Wakasa-Morimoto, Masanori Kobayashi et al. · Antiviral Research · 2008 · 50 citations

Life Sciences, Microbiology, Molecular Biology +17

Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzodiazepines

Kentaro Hirai, T. ISHIBA, Hirohiko Sugimoto et al. · Journal of Medicinal Chemistry · 1980 · 37 citations

Medicine, Medicinal Chemistry, Pharmacology +13