Role of the ABC Transporter Mdl1 in Peptide Export from Mitochondria

Lesley Young, Klaus Leonhard, Takashi Tatsuta, +2

Science

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

Matthew Boyles, Lesley Young, David M. Brown, +8

Toxicology in Vitro

InflammationLength DependentImmunologyPathologyMulti-walled Carbon Nanotube +5

The Rat cim Effect: TAP Allele-Dependent Changes in a Class I MHC Anchor Motif and Evidence Against C-Terminal Trimming of Peptides in the ER

Simon J. Powis, Lesley Young, Etienne Joly, +6

Immunity

FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity

Matthew Kraman, Mustapha Faroudi, Natalie L. Allen, +12

Clinical Cancer Research

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell–dependent mechanism

Kenneth K. Wong, Matthew J. Carpenter, Lesley Young, +12

Journal of Clinical Investigation

Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell–dependent mechanism

Kenneth K. Wong, Matthew J. Carpenter, Lesley Young, +12

Journal of Clinical Investigation

A Novel Murine GITR Ligand Fusion Protein Induces Antitumor Activity as a Monotherapy That Is Further Enhanced in Combination with an OX40 Agonist

Rebecca Leyland, Amanda Watkins, Kathy Mulgrew, +19

Clinical Cancer Research

A Phase 1 First-in-Human Study of FS118, a Tetravalent Bispecific Antibody Targeting LAG-3 and PD-L1 in Patients with Advanced Cancer and PD-L1 Resistance

Timothy A. Yap, Patricia LoRusso, Deborah J. Wong, +19

Clinical Cancer Research

MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential

Natalie J. Tigue, Lisa Bamber, John L. Andrews, +24

OncoImmunology

Silver nanoparticles promote the emergence of heterogeneic human neutrophil sub-populations

Jennifer A. Fraser, Sadie Kemp, Lesley Young, +4

Scientific Reports