Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Sadanand Fulzele, Bharati Mendhe, Andrew Khayrullin, +5

Aging

Activation of PERK Elicits Memory Impairment through Inactivation of CREB and Downregulation of PSD95 After Traumatic Brain Injury

Tanusree Sen, Rajaneesh K. Gupta, Helen Kaiser, +1

Journal of Neuroscience

Kynurenine, a Tryptophan Metabolite That Increases with Age, Induces Muscle Atrophy and Lipid Peroxidation

Helen Kaiser, Kanglun Yu, Chirayu D. Pandya, +6

Oxidative Medicine and Cellular Longevity

Bone Marrow Derived Extracellular Vesicles Activate Osteoclast Differentiation in Traumatic Brain Injury Induced Bone Loss

Quante Singleton, Kumar Vaibhav, Molly Braun, +15

Cells

Traumatic Brain InjuryImmune RegulationImmunologyCell DeathBone Repair +25

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo

Jessica L. Pierce, Rachel L. Roberts, Kanglun Yu, +9

Experimental Gerontology

MechanobiologyTissue EngineeringEngineeringBone Morphogenic ProteinMedicine +11

The Glucocorticoid Receptor in Osterix-Expressing Cells Regulates Bone Mass, Bone Marrow Adipose Tissue, and Systemic Metabolism in Female Mice During Aging

Jessica L. Pierce, Anuj K. Sharma, Rachel L. Roberts, +16

Journal of Bone and Mineral Research

Accumulation of kynurenine elevates oxidative stress and alters microRNA profile in human bone marrow stromal cells

Sherwood Dalton, Kathryn E. Smith, Kanwar Singh, +8

Experimental Gerontology

ImmunologyCell DeathSmall RnaMicrorna DetectionMedicine +4

Age-related increase of kynurenine enhances miR29b-1-5p to decrease both CXCL12 signaling and the epigenetic enzyme Hdac3 in bone marrow stromal cells

Ahmed M. Elmansi, Khaled A. Hussein, Sudharsan Periyasamy‐Thandavan, +23

Bone Reports

Picolinic acid, a tryptophan oxidation product, does not impact bone mineral density but increases marrow adiposity

Kehong Ding, Meghan E. McGee‐Lawrence, Helen Kaiser, +13

Experimental Gerontology

Metabolic SyndromeNutritionBone HealthBiochemistryLipid Peroxidation +12