Paul Severin

Effects of Fostamatinib on the Pharmacokinetics of Oral Contraceptive, Warfarin, and the Statins Rosuvastatin and Simvastatin: Results From Phase I Clinical Studies

Paul Martin, Michael Gillen, James M. Ritter et al. · Drugs in R&D · 2016 · 45 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +13

Effects of cytochrome P450 (CYP3A4 and CYP2C19) inhibition and induction on the exposure of selumetinib, a MEK1/2 inhibitor, in healthy subjects: results from two clinical trials

Angela W. Dymond, Karen So, Paul Martin et al. · European Journal of Clinical Pharmacology · 2016 · 29 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Determination of Selumetinib, N-Desmethyl Selumetinib and Selumetinib Amide in Human Biological Samples by LC–MS/MS

Paul Severin, Christopher J. Bailey, Meng Chen et al. · Bioanalysis · 2016 · 22 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

Pharmacokinetics of a Single Oral Dose of the MEK1/2 Inhibitor Selumetinib in Subjects With End‐Stage Renal Disease or Varying Degrees of Hepatic Impairment Compared With Healthy Subjects

Angela W. Dymond, Paul Martin, Karen So et al. · The Journal of Clinical Pharmacology · 2016 · 15 citations · Full text

Pharmacy, Clinical Pharmacokinetics, Pharmacology +15

Novel LC–MS/MS Method for the Determination of Selumetinib (AZD6244) in Whole Blood Collected with Volumetric Absorptive Microsampling

Ramakrishna Reddy Voggu, Theodore S Brus, Chineta T Barksdale et al. · Bioanalysis · 2020 · 10 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +13