TC-5619: An alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

Terry A. Hauser, Aaron Kucinski, Kristen G. Jordan, +8

Biochemical Pharmacology

PsychiatryMedicineCognitive DysfunctionNicotinePsychopharmacology +8

Systemic Administration of an Alpha-7 Nicotinic Acetylcholine Agonist Reverses Neuropathic Pain in Male Sprague Dawley Rats

Lisa C. Loram, Frederick R. Taylor, Keith A. Strand, +11

Journal of Pain

Pain TherapyHealth SciencesPain MedicineMedicineNeuropathic Pain +8

α4β2 nicotinic receptors play a role in the nAChR-mediated decline in l-dopa-induced dyskinesias in parkinsonian rats

Maryka Quik, Carla Cristian Campos, Tanuja Bordia, +5

Neuropharmacology

Neurodegenerative DiseasesMedicineSynaptic TransmissionNeurotransmitterNeuropharmacology +9

TC-8831, a nicotinic acetylcholine receptor agonist, reduces l-DOPA-induced dyskinesia in the MPTP macaque

Tom H. Johnston, Philippe Huot, Susan H. Fox, +8

Neuropharmacology

NeurophysiologyMedicineNeuropharmacologyPharmacotherapyNeuroscience +7

Characterization of the discriminative stimulus effects of N -methyl- D -aspartate ligands under different ethanol training conditions in the cynomolgus monkey ( Macaca fascicularis )

Jeffrey A. Vivian, Courtney A. Waters, Kendall T. Szeliga, +2

Psychopharmacology

Behavioral NeuroscienceNeurophysiologyMedicinePhysiologyDiscriminative Stimulus Effects +11

Discovery of 3-(5-Chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a Novel Highly Selective α4β2 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders

Anatoly Mazurov, Lan Miao, Balwinder S. Bhatti, +13

Journal of Medicinal Chemistry

Psychotropic MedicationPeptide SciencePharmacotherapyCognitive DisordersPharmaceutical Chemistry +18

Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: Correlation with desensitization of α4β2* receptors

Yun-De Xiao, Kristen G. Jordan, Philip S. Hammond, +8

European Journal of Pharmaceutical Sciences

Molecular PharmacologyHealth SciencesPain MedicineSynaptic TransmissionPhysiology +11

KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism

Nibedita Chattopadhyay, Allison Berger, Erik Koenig, +16

PLoS ONE

ImmunologyPathologyKras-wt Sw48 CellsCancer BiologyTumor Biology +15

Novel nicotinic acetylcholine receptor agonists containing carbonyl moiety as a hydrogen bond acceptor

Anatoly Mazurov, David C. Kombo, Srinivasa Rao Akireddy, +5

Bioorganic & Medicinal Chemistry Letters

Carbonyl MoietyBiochemistryFunctional SelectivityNatural SciencesMedicine +7

Neuronal nicotinic receptor agonists ameliorate spontaneous motor asymmetries and motor discoordination in a unilateral mouse model of Parkinson's disease

Aaron Kucinski, Scott R. Wersinger, Ewa K. Stachowiak, +7

Pharmacology Biochemistry and Behavior

NeurophysiologyNeuroanatomyPhysiologyMotor DiscoordinationSpontaneous Motor Asymmetries +10