Tumor Heterogeneity Correlates with Less Immune Response and Worse Survival in Breast Cancer Patients

Kerry-Ann McDonald, Tsutomu Kawaguchi, Qianya Qi, +8

Annals of Surgical Oncology

Immune EvasionBreast OncologyCancer ImmunosurveillanceBreast Cancer PatientsTumor Heterogeneity Correlates +8

CXCL12/CXCR4 Blockade by Oncolytic Virotherapy Inhibits Ovarian Cancer Growth by Decreasing Immunosuppression and Targeting Cancer-Initiating Cells

Margaret Gil, Marcin Komorowski, Mukund Seshadri, +5

The Journal of Immunology

ImmunologyImmunoeditingImmunotherapyTumor BiologyOvarian Cancer +16

The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

Antonino B. D’Assoro, T Liu, Cosima Quatraro, +17

Oncogene

Epithelial-to-mesenchymal TransitionCell RegulationMedicineCancer Cell BiologyProtein Kinase +8

Entinostat plus Pembrolizumab in Patients with Metastatic NSCLC Previously Treated with Anti–PD-(L)1 Therapy

Matthew D. Hellmann, Pasi A. Jänne, Mateusz Opyrchal, +17

Clinical Cancer Research

Oncolytic measles virus strains have significant antitumor activity against glioma stem cells

Cory Allen, Mateusz Opyrchal, Ileana Aderca, +4

Gene Therapy

Neuro-oncologyOncolytic MeaslesGliomaMedicineSignificant Antitumor Activity +9

The 3′ Untranslated Region of Sindbis Virus Represses Deadenylation of Viral Transcripts in Mosquito and Mammalian Cells

Nicole L. Garneau, Kevin J. Sokoloski, Mateusz Opyrchal, +3

Journal of Virology

Viral ReplicationViral Polymerase StructureMolecular BiologySinv RnasVirus Gene +15

Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity

Ateeq Khaliq, Meenakshi Rajamohan, Omer Saeed, +16

Nature Genetics

Functional GenomicsPancreatic CancerSpatial TranscriptomicsTumor HeterogeneityMedicine +9

Prognostic Significance of Stromal Versus Intratumoral Infiltrating Lymphocytes in Different Subtypes of Breast Cancer Treated With Cytotoxic Neoadjuvant Chemotherapy

Thaer Khoury, Vidya Nagrale, Mateusz Opyrchal, +3

Applied immunohistochemistry & molecular morphology

Dephosphorylation of HuR Protein during Alphavirus Infection Is Associated with HuR Relocalization to the Cytoplasm

Alexa Dickson, John R. Anderson, Michael D. Barnhart, +7

Journal of Biological Chemistry

Viral ReplicationMolecular VirologyHur ProteinPathogenesisImmunology +3

Effective Radiovirotherapy for Malignant Gliomas by Using Oncolytic Measles Virus Strains Encoding the Sodium Iodide Symporter (MV-NIS)

Mateusz Opyrchal, Cory Allen, Ianko Iankov, +4

Human Gene Therapy

ImmunologyPathologyHigh-grade GliomasImmunotherapyGlioma +21