Amitriptyline suppresses neuroinflammation and up-regulates glutamate transporters in morphine-tolerant rats

Yueh-Hua Tai, Yu-Hsueh Wang, Jhi‐Joung Wang, +3

Pain

Morphine ToleranceNeuropeptidesPain MedicineMolecular PainPharmacotherapy +21

Amitriptyline preserves morphine’s antinociceptive effect by regulating the glutamate transporter GLAST and GLT-1 trafficking and excitatory amino acids concentration in morphine-tolerant rats

Yueh-Hua Tai, Yu-Hsueh Wang, Ru‐Yin Tsai, +5

Pain

Morphine TolerancePain MedicineMolecular PainPharmacotherapyGlutamate Transporter Glast +20

Amitriptyline Suppresses Neuroinflammation-dependent Interleukin-10-p38 Mitogen-activated Protein Kinase-Heme Oxygenase-1 Signaling Pathway in Chronic Morphine-infused Rats

Yueh-Hua Tai, Ru‐Yin Tsai, Shinn‐Long Lin, +4

Anesthesiology

Ultra-Low-Dose Naloxone Restores the Antinociceptive Effect of Morphine and Suppresses Spinal Neuroinflammation in PTX-Treated Rats

Ru‐Yin Tsai, Fong-Lin Jang, Yueh-Hua Tai, +3

Neuropsychopharmacology

Ptx-treated RatsHealth SciencesPain MedicineMedicinePostoperative Pain Management +12

Amitriptyline induces nuclear transcription factor-κB–dependent glutamate transporter upregulation in chronic morphine-infused rats

Yueh-Hua Tai, Ru-Ying Tsai, Yih-Cherng Wang, +4

Neuroscience

Molecular PharmacologyMolecular NeuroscienceAddictionSynaptic TransmissionPhysiology +10

Ultra-low dose naloxone upregulates interleukin-10 expression and suppresses neuroinflammation in morphine-tolerant rat spinal cords

Shinn‐Long Lin, Ru‐Yin Tsai, Yueh-Hua Tai, +4

Behavioural Brain Research

Pain ResearchSpinal Cord InjuryHealth SciencesPain MedicineMedicine +12

Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin-treated rats by reversing the coupling of μ-opioid receptors from Gs-protein to coupling to Gi-protein

R.-Y. Tsai, Yueh-Hua Tai, J I Tzeng, +3

Neuroscience

Molecular PharmacologyPain DisordersHealth SciencesPain MedicineMedicine +13

Functional interaction of AT1 and AT2 receptors in fructose-induced insulin resistance and hypertension in rats

Po‐Shiuan Hsieh, Yueh-Hua Tai, Ching‐Hui Loh, +3

Metabolism

Functional InteractionInsulin SignalingGastrointestinal Peptide HormoneOxidative StressMolecular Pharmacology +15

N-Methyl-d-aspartate receptor antagonist MK-801 suppresses glial pro-inflammatory cytokine expression in morphine-tolerant rats

Ching-Hang Liu, Chen-Hwen Cherng, Shinn‐Long Lin, +4

Pharmacology Biochemistry and Behavior

NeuroinflammationInflammationAnti-inflammatoryHealth SciencesPain Medicine +10

Ultra-low dose naloxone restores the antinociceptive effect of morphine in pertussis toxin–treated rats and prevents glutamate transporter downregulation by suppressing the p38 mitogen-activated protein kinase signaling pathway

R.-Y. Tsai, Yueh-Hua Tai, J I Tzeng, +6

Neuroscience

Molecular PharmacologyHealth SciencesPain MedicineMedicineMolecular Pain +12