Efficacy of Larotrectinib in <i>TRK</i> Fusion–Positive Cancers in Adults and Children

Alexander Drilon, Theodore W. Laetsch, Shivaani Kummar, +35

New England Journal of Medicine

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

Kathryn Blaschke, Kevin Ebata, Mohammad M. Karimi, +9

Nature

ChromatinEs CellsDevelopmental BiologyCell RegulationChromatin Remodeling +11

Efficacy of Selpercatinib in <i>RET</i> Fusion–Positive Non–Small-Cell Lung Cancer

Alexander Drilon, Geoffrey R. Oxnard, Daniel Shao-Weng Tan, +42

New England Journal of Medicine

Efficacy of Selpercatinib in <i>RET</i> -Altered Thyroid Cancers

Lori J. Wirth, Eric J. Sherman, Bruce Robinson, +37

New England Journal of Medicine

Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study

Theodore W. Laetsch, Steven G. DuBois, Leo Mascarenhas, +15

The Lancet Oncology

Tumoral PathologyMedicinePathologyPaediatric Solid TumoursCancer Genetics +5

Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study

Anthony R. Mato, Nirav N. Shah, Wojciech Jurczak, +41

The Lancet

Phase 1/2Lymphoid NeoplasiaMedicineMalignant Blood DisorderImmunology +4

Selective RET kinase inhibition for patients with RET-altered cancers

Vivek Subbiah, Vamsidhar Velcheti, Brian B. Tuch, +21

Annals of Oncology

A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion–Positive Solid Tumors

Alexander Drilon, Ramamoorthy Nagasubramanian, James F. Blake, +31

Cancer Discovery

RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies

Benjamin Solomon, Lavinia Tan, Stephen Q. Wong, +27

Journal of Thoracic Oncology

Resistance to TRK inhibition mediated by convergent MAPK pathway activation

Emiliano Cocco, Alison M. Schram, Amanda Kulick, +26

Nature Medicine

Signal TransductionCell RegulationMolecular PathwaySignaling PathwayReceptor Tyrosine Kinase +7