21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T509,Regulatory T (T_reg) cells play a vital role in maintaining maternal immune tolerance to the semiallogeneic fetus during pregnancy. T_reg cell population heterogeneity and tissue-specific functions in the human decidua remain largely unknown. Here, using single-cell transcriptomic and T cell receptor sequencing of human CD4⁺ T cells from first-trimester deciduae and matched peripheral blood of pregnant women, we identified a highly activated, immunosuppressive CCR8⁺ T_reg cell subset specifically enriched in the decidua (dT_reg cells). CCR8⁺ dT_reg cells were decreased in patients with recurrent pregnancy loss (RPL) and an abortion-prone mouse model. Depletion of CCR8⁺ dT_reg cells increased susceptibility to fetal loss, with altered decidual immune profiles. Adoptive transfer of CCR8⁺ T_reg cells rescued fetal loss in abortion-prone mice. The CCR8 ligand CCL1 was mainly produced by decidual CD49a⁺ natural killer cells and was significantly decreased in patients with RPL. Our data demonstrate that CCR8⁺ dT_reg cells are required to maintain maternal-fetal tolerance and highlight potential avenues for RPL therapies.

#	Concept	H-Index	Publications	Citations
1	Medicine	1	1	13
2	Biology	1	1	13
3	Gastroenterology	1	1	13
4	Metabolism	1	1	13
5	Pathology	1	1	13

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