Thomas Gelzleichter

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

Rafael Ponce, Leslie W. Abad, Lakshmi Amaravadi et al. · Regulatory Toxicology and Pharmacology · 2009 · 264 citations

Allergy, Immunotoxicology, Medicine +10

GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer

Jun Liang, Robert A. Blake, Jae H. Chang et al. · Journal of Medicinal Chemistry · 2021 · 130 citations · Full text

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

Ganesh Kolumam, Mark Z. Chen, Raymond K. Tong et al. · EBioMedicine · 2015 · 107 citations · Full text

Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans

Amos Baruch, Chin Wong, Leslie W. Chinn et al. · Proceedings of the National Academy of Sciences · 2020 · 89 citations · Full text

A Soluble BAFF Antagonist, BR3-Fc, Decreases Peripheral Blood B Cells and Lymphoid Tissue Marginal Zone and Follicular B Cells in Cynomolgus Monkeys

Yulia Vugmeyster, Dhaya Seshasayee, Wesley Chang et al. · American Journal Of Pathology · 2006 · 78 citations · Full text

Inflammation, Cynomolgus Monkeys, Follicular B Cells +10