Concepedia

Manuela M. Brütsch

MM

Statistics

Publications

6

Citations

135

H-Index

6

Active since

2016

Affiliations

Scripps Research Institute(Current)

Manuela M. Brütsch is an author at Scripps Research Institute specializing in medicinal chemistry, drug discovery, and potency optimization.

Publications per year

2016–2020

6

Publications

6

Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity

Oliver Allemann, Manuela M. Brütsch, John C. Lukesh et al. · Journal of the American Chemical Society · 2016 · 39 citations · Full text

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Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer–dimer interface

Daniel W. Carney, John C. Lukesh, Daniel M. Brody et al. · Proceedings of the National Academy of Sciences · 2016 · 29 citations · Full text

, , +17

Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity

Shouliang Yang, Kuppusamy Sankar, Colin K. Skepper et al. · Chemical Science · 2016 · 22 citations · Full text

, , +11

Vinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance

John C. Lukesh, Daniel W. Carney, Huijun Dong et al. · Journal of Medicinal Chemistry · 2017 · 21 citations · Full text

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Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers

A. Dolbois, Laurent Batiste, L. Wiedmer et al. · ACS Medicinal Chemistry Letters · 2020 · 13 citations · Full text

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