Jessica Sigvardson

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

Jinar Rostami, Staffan Holmqvist, Veronica Lindström et al. · Journal of Neuroscience · 2017 · 324 citations · Full text

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

Veronica Lindström, Gabriel Gustafsson, Laurie H. Sanders et al. · Molecular and Cellular Neuroscience · 2017 · 216 citations

Extensive Uptake, Neurodegenerative Diseases, Mitochondrial Damage +11

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

Eva Nordström, Fredrik Eriksson, Jessica Sigvardson et al. · Neurobiology of Disease · 2021 · 49 citations · Full text

Immunology, Neurochemical Biomarkers, Therapeutics +23

Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy

Martin Kallab, Marcos Herrera-Vaquero, Malin Johannesson et al. · Frontiers in Neuroscience · 2018 · 34 citations · Full text

Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways

Leire Almandoz-Gil, Hedvig Welander, Elisabet Ihse et al. · Free Radical Biology and Medicine · 2017 · 26 citations · Full text