Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

Masakazu Imamura, Keita Nakanishi, Takayuki Suzuki, +14

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryBenzothiophene StructureMedicineDiabetes +8

Total Synthesis of Natural PI-091, a New Platelet Aggregation Inhibitor of Microbial Origin

Ryota Shiraki, Akihiko Sumino, Kin‐ichi Tadano, +1

The Journal of Organic Chemistry

Bioorganic ChemistryOrganic ChemistryMedicinal ChemistrySinglet OxygenGamma-ketal Carbon +14

Total Syntheses of Natural Pseurotins A, F2, and Azaspirene

Shinya Aoki, Takahiro Oi, Kazuya Shimizu, +3

Bulletin of the Chemical Society of Japan

Diversity Oriented SynthesisDerivativesBiochemistryChitin SynthaseMedicine +11

Nickel-Catalyzed Addition of C–C Bonds of Amides to Strained Alkenes: The 1,2-Carboaminocarbonylation Reaction

Yuri Ito, Syun Nakatani, Ryota Shiraki, +2

Journal of the American Chemical Society

Cross-coupling ReactionNickel-catalyzed AdditionEngineeringNickel CatalystOrganic Chemistry +8

Total Synthesis of PI-091

Ryota Shiraki

Tetrahedron Letters

Combinatorial ChemistryTotal SynthesisOrganic ChemistryChemistrySynthesis Method +1

Total synthesis of PI-091

Ryota Shiraki, Akihiko Sumino, Kin‐ichi Tadano, +1

Tetrahedron Letters

Combinatorial ChemistryTotal SynthesisOrganic ChemistryChemistrySynthesis Method +1

Total Synthesis of (−)-Verrucarol¹

Jun Ishihara, Rie Nonaka, Yuki Terasawa, +5

The Journal of Organic Chemistry

Dieckmann CyclizationBiochemistryNatural SciencesTotal SynthesisOrganic Chemistry +8

Total Syntheses of Natural Pseurotins A and F2 and Azaspirene

Kin-ichi Tadano, Shin‐ya Aoki, Takahiro Oi, +3

Heterocycles

BiosynthesisBioorganic ChemistryEngineeringBiochemistryRelated Azaspirene +9

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a

Kenichi Onda, Takayuki Suzuki, Ryota Shiraki, +8

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryNatural Sciences5-Chloro-n-aryl-1h-indole-2-carboxamide DerivativesPharmacology +2

Development and validation of a Fall Risk Assessment Index for dialysis patients

Kenichi Kono, Yusuke Nishida, Hiroki Yabe, +4

Clinical and Experimental Nephrology

Fall PreventionHemodialysisHealth PolicyDisease Risk AssessmentMedicine +13