New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

Dominik Sturm, Brent A. Orr, Umut H. Toprak, +107

Cell

Neuro-oncologyMolecular ClassificationCerebral OrganoidNeurologyNeuroscience +6

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

Pascal D. Johann, Serap Erkek, Marc Zapatka, +55

Cancer Cell

ChromatinChromatin RemodelingMedicineGeneticsEpigenetic Change +8

Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort

Sebastian M. Waszak, Paul A. Northcott, Ivo Buchhalter, +83

The Lancet Oncology

HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC- Driven Medulloblastoma

Yanxin Pei, Kun-Wei Liu, Jun Wang, +21

Cancer Cell

Myc- Driven MedulloblastomaMalignant DiseaseOncogenic AgentPi3k Antagonists CooperateMedicine +7

A biobank of patient-derived pediatric brain tumor models

Sebastian Brabetz, Sarah Leary, Susanne Gröbner, +24

Nature Medicine

Neuro-oncologyNeuroimaging BiomarkersPediatric Brain TumorsNeuroimagingNeurology +3

The molecular landscape of ETMR at diagnosis and relapse

Sander Lambo, Susanne Gröbner, Tobias Rausch, +62

Nature

Molecular CharacterizationNatural SciencesMolecular BiologyMolecular PathologyMolecular Landscape +2

Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling

Antoine Forget, Loredana Martignetti, Stéphanie Puget, +44

Cancer Cell

Signal TransductionGroup 4PathologyProtein PhosphorylationIntegrative Phosphoproteomic Profiling +6

PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models

Terrence F. Meehan, Nathalie Conte, Theodore C. Goldstein, +51

Cancer Research

Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children’s Oncology Group Randomized ACNS0332 Trial

Eugene Hwang, Marcel Kool, Peter C. Burger, +19

Journal of Clinical Oncology

YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

Kristian W. Pajtler, Yiju Wei, Konstantin Okonechnikov, +29

Nature Communications