Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5/p35 pathway

Rodrigo A. Quintanilla, Daniel Orellana, Christian González‐Billault, +1

Experimental Cell Research

InflammationCytokineNeurodegenerative DiseasesTau ProteinAlzheimer's Disease +11

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice

Cinzia Vicidomini, Luisa Ponzoni, Dmitry Lim, +14

Molecular Psychiatry

Mglu5 ReceptorsBehavioral NeuroscienceShank3 Knock-out MiceMedicineBehavioral Pharmacology +11

Coenzyme A corrects pathological defects in human neurons of <scp>PANK</scp> 2‐associated neurodegeneration

Daniel Orellana, Paolo Santambrogio, Alicia Rubio, +13

EMBO Molecular Medicine

Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons

Daniel Orellana, Rodrigo A. Quintanilla, Christian González‐Billault, +1

Neurotoxicity Research

InflammationCytokineSignal TransductionCell SignalingJaks/stats Pathway +13

Stem Cell Modeling of Neuroferritinopathy Reveals Iron as a Determinant of Senescence and Ferroptosis during Neuronal Aging

Anna Cozzi, Daniel Orellana, Paolo Santambrogio, +12

Stem Cell Reports

Neuroprotective effect of TNFα against the β-amyloid neurotoxicity mediated by CDK5 kinase

Daniel Orellana, Rodrigo A. Quintanilla, Ricardo B. Maccioni

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Neurodegenerative Diseasesβ-Amyloid NeurotoxicityMedicineCell DeathBrain-immune Interaction +8

Comparative neuronal differentiation of self-renewing neural progenitor cell lines obtained from human induced pluripotent stem cells

Chiara Verpelli, Luigi Carlessi, Giulia Bechi, +8

Frontiers in Cellular Neuroscience

Progenitor CellsAdult Stem CellCell DifferentiationComparative Neuronal DifferentiationRegenerative Medicine +20

Lentiviral Vectors to Study the Differential Function of ERK1 and ERK2 MAP Kinases

Marzia Indrigo, Alessandro Papale, Daniel Orellana, +1

Methods in molecular biology

Nuclear ERK1/2 signaling potentiation enhances neuroprotection and cognition via Importinα1/KPNA2

Marzia Indrigo, Ilaria Morella, Daniel Orellana, +22

EMBO Molecular Medicine

cdk5 modulates β‐ and δ‐catenin/Pin1 interactions in neuronal cells

Juan Pablo Muñoz, Claudia Huichalaf, Daniel Orellana, +1

Journal of Cellular Biochemistry

Cdk5-activator P35Molecular NeuroscienceSignal TransductionDevelopmental BiologySignaling Pathway +11