Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells.

Andrew D. Burdick, John W. Davis, Ke Jian Liu, +4

PubMed

Chemoprevention StrategyBreast Epithelial CellsCell SignalingGrowth FactorMedicine +11

Sequence motifs associated with hepatotoxicity of locked nucleic acid—modified antisense oligonucleotides

Andrew D. Burdick, Simone Sciabola, Srinivasa R. Mantena, +10

Nucleic Acids Research

Molecular BiologyCell DeathGlucocorticoid ReceptorNucleic Acid BiomarkersToxicological Mechanism +22

Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species

Honglian Shi, Graham S. Timmins, Michael Monske, +6

Archives of Biochemistry and Biophysics

BiochemistryElectron Paramagnetic ResonanceMagnetic ResonanceReactive Oxygen SpecieMedicine +3

Deregulation of tumor angiogenesis and blockade of tumor growth in PPARβ‐deficient mice

Sabine Müller‐Brüsselbach, Martin Kömhoff, Markus Rieck, +8

The EMBO Journal

Ligand activation of peroxisome proliferator-activated receptor-β/δ(PPARβ/δ) inhibits cell growth of human N/TERT-1 keratinocytes

Andrew D. Burdick, Moses T. Bility, Elizabeth E. Girroir, +4

Cellular Signalling

Ligand ActivationSkin DevelopmentSignal TransductionMolecular PhysiologyMedicine +7

Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.

John W. Davis, Fredine T. Lauer, Andrew D. Burdick, +2

PubMed

Chemoprevention StrategyApoptosisCell DeathCell ProliferationGrowth Factor Alpha +15

Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model

David Suhy, Shih-Chu Kao, Tin K. Mao, +18

Molecular Therapy

Comparison of Hepatic Transcription Profiles of Locked Ribonucleic Acid Antisense Oligonucleotides: Evidence of Distinct Pathways Contributing to Non-target Mediated Toxicity in Mice

Satoko Kakiuchi-Kiyota, Petra Koza‐Taylor, Srinivasa R. Mantena, +9

Toxicological Sciences

PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells

Andrew D. Burdick, Irena Ivnitski‐Steele, Fredine T. Lauer, +1

Carcinogenesis

The aryl hydrocarbon receptor antagonist, 3′methoxy-4′nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line

John W. Davis, Andrew D. Burdick, Fredine T. Lauer, +1

Toxicology and Applied Pharmacology

Molecular PharmacologyGrowth Factor2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent RegulationApoptosisMedicine +7