The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury

Naijun Miao, Fan Yin, Hongyan Xie, +15

Kidney International

InflammationUrologyRenal FunctionUrinary Il-18 ExcretionMedicine +13

Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus

Naijun Miao, Zhuning Wang, Qinlan Wang, +18

Nature Communications

Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response

Yina Wang, Yuanyuan Wang, Jin Wang, +3

Journal for ImmunoTherapy of Cancer

Ferritin triggers neutrophil extracellular trap-mediated cytokine storm through Msr1 contributing to adult-onset Still’s disease pathogenesis

Jinchao Jia, Mengyan Wang, Jianfen Meng, +21

Nature Communications

c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling

Yang Shen, Naijun Miao, Bao Wang, +8

Kidney International

InflammationFibrosisMedicineRenal PathologyRenal Inflammation +10

PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow

Yao Yu, Rongrong Wang, Naijun Miao, +6

Nature Communications

Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts

Yang Shen, Naijun Miao, Jinlan Xu, +6

International Journal of Molecular Sciences

Renal PathologyRenal InflammationPathologyRenal FibrosisAng Ii +27

Caspase-11 promotes NLRP3 inflammasome activation via the cleavage of pannexin1 in acute kidney disease

Fan Yin, Peiqing Zheng, Liuqi Zhao, +13

Acta Pharmacologica Sinica

InflammationCytokineInflammatory DiseaseImmunologyRenal Inflammation +8

Caspase-11 promotes renal fibrosis by stimulating IL-1β maturation via activating caspase-1

Naijun Miao, Hongyan Xie, Dan Xu, +13

Acta Pharmacologica Sinica

Renal PathologyImmunologyRenal InflammationCell DeathPathology +14

Renalase attenuates hypertension, renal injury and cardiac remodelling in rats with subtotal nephrectomy

Jianyong Yin, Zeyuan Lu, Feng Wang, +4

Journal of Cellular and Molecular Medicine

HypertensionHeart FailureRenal PathologyRenal InflammationSubtotal Nephrectomy +23