Yoshitaka Tayama

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara et al. · Drug Metabolism and Disposition · 2011 · 80 citations

Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver

Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama et al. · Drug Metabolism and Disposition · 2008 · 52 citations

Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes

Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara et al. · Drug Metabolism and Disposition · 2012 · 45 citations

Developmental Changes of Aldehyde Oxidase Activity in Young Japanese Children

Yoshitaka Tayama, Katsushi Miyake, Kazumi Sugihara et al. · Clinical Pharmacology & Therapeutics · 2007 · 44 citations

ESTIMATION OF ALDEHYDE OXIDASE ACTIVITY IN VIVO FROM CONVERSION RATIO OF N1-METHYLNICOTINAMIDE TO PYRIDONES, AND INTRASPECIES VARIATION OF THE ENZYME ACTIVITY IN RATS

Kazumi Sugihara, Yoshitaka Tayama, Kazuhiro Shimomiya et al. · Drug Metabolism and Disposition · 2005 · 39 citations