Aaron Ruff

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated <i>in Vitro in Vivo</i> Extrapolation Perspective Using Ketoconazole as a Model Drug

Shriram M. Pathak, Aaron Ruff, Edmund Kostewicz et al. · Molecular Pharmaceutics · 2017 · 90 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling

Aaron Ruff, Tom Fiolka, Edmund Kostewicz · European Journal of Pharmaceutical Sciences · 2016 · 65 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Advances and challenges in PBPK modeling – Analysis of factors contributing to the oral absorption of atazanavir, a poorly soluble weak base

Mark Berlin, Aaron Ruff, Filippos Kesisoglou et al. · European Journal of Pharmaceutics and Biopharmaceutics · 2015 · 46 citations

Pharmacy, Pharmacokinetics, Pharmacology +16

A toolbox for the upscaling of ethanolic human serum albumin (HSA) desolvation

Matthias G. Wacker, Anja Zensi, Jürgen Kufleitner et al. · International Journal of Pharmaceutics · 2011 · 40 citations

Natural Sciences, Biochemistry, Analytical Chemistry +3

Evaluating the predictability of the in vitro transfer model and in vivo rat studies as a surrogate to investigate the supersaturation and precipitation behaviour of different Albendazole formulations for humans

Aaron Ruff, René Holm, Edmund Kostewicz · European Journal of Pharmaceutical Sciences · 2017 · 17 citations

Pharmacy, Pharmaceutics, Pharmacokinetics +13