Allison Amore

Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

Tiago F. Outeiro, Eirene Kontopoulos, Stephen M. Altmann et al. · Science · 2007 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

Ruth Luthi‐Carter, David Taylor, Judit Pallos et al. · Proceedings of the National Academy of Sciences · 2010 · 340 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

Michele M. Maxwell, Elizabeth M. Tomkinson, Johnathan Nobles et al. · Human Molecular Genetics · 2011 · 205 citations · Full text

Life Sciences, Neurobiology, Neuroscience +15

A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase

David Taylor, Uma Balabadra, Zhongmin Xiang et al. · ACS Chemical Biology · 2011 · 131 citations

Life Sciences, Neuroscience, Pharmacology +17

Pharmacological inhibition of PARP-1 reduces α-synuclein- and MPP+-induced cytotoxicity in Parkinson’s disease in vitro models

Tiago F. Outeiro, Tom N. Grammatopoulos, Steven Altmann et al. · Biochemical and Biophysical Research Communications · 2007 · 78 citations

Life Sciences, Neuroscience, Pharmacology +17