Thomas C. Baddeley

Complex Disposition of Methylthioninium Redox Forms Determines Efficacy in Tau Aggregation Inhibitor Therapy for Alzheimer’s Disease

Thomas C. Baddeley, Jennifer McCaffrey, John M. D. Storey et al. · Journal of Pharmacology and Experimental Therapeutics · 2014 · 126 citations

Medicine, Medicinal Chemistry, Pharmacology +17

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

John Steven, Mischa Müller, Miguel F. Carvalho et al. · Frontiers in Immunology · 2017 · 47 citations · Full text

Life Sciences, Biotechnology, Immunology +17

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

Youssra K. Al‐Hilaly, Saskia J. Pollack, Janet E. Rickard et al. · Journal of Molecular Biology · 2018 · 45 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

B. Schelter, Helen Shiells, Thomas C. Baddeley et al. · Journal of Alzheimer s Disease · 2019 · 45 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Helen Shiells, B. Schelter, Peter Bentham et al. · Journal of Alzheimer s Disease · 2020 · 35 citations · Full text

Medicine, Neurology, Pharmacology +17