Hidetoshi Takada

Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome

Yoshiyuki Minegishi, Masako Saitō, Shigeru Tsuchiya et al. · Nature · 2007 · 1K citations

Transcriptional Regulation, Disease Mechanism, Genetic Disorder +9

Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

Nobutaka Suzuki, Shinobu Suzuki, Gordon S. Duncan et al. · Nature · 2002 · 846 citations

Inflammation, Toll-like Receptors, Cytokine +10

Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity

Yoshiyuki Minegishi, Masako Saitō, Tomohiro Morio et al. · Immunity · 2006 · 687 citations · Full text

Inflammation, Cytokine, Signal Transduction +13

Clinical Features and Outcome of Patients With IRAK-4 and MyD88 Deficiency

Capucine Pïcard, Horst von Bernuth, Pegah Ghandil et al. · Medicine · 2010 · 420 citations · Full text

Selective predisposition to bacterial infections in IRAK-4–deficient children: IRAK-4–dependent TLRs are otherwise redundant in protective immunity

Cheng‐Lung Ku, Horst von Bernuth, Capucine Pïcard et al. · The Journal of Experimental Medicine · 2007 · 390 citations · Full text