Technical progresses for PVC production

Yasuharu Saeki, Takashi Emura

Progress in Polymer Science

EngineeringTechnical ProgressesSolar PowerBuilding-integrated PhotovoltaicsSystems Engineering +3

Designed Ligands as Probes for the Catalytic Binding Mode in Mo-Catalyzed Asymmetric Allylic Alkylation We thank the National Science Foundation and the National Institutes of Health for their generous support of the work carried out at Stanford. I.H. thanks the Japan Society for the Promotion of Science for a postdoctoral fellowship. Mass spectra were provided by the Mass Spectrometry Facility at the University of California, San Francisco, which is supported by the NIH Division of Research Resources.

Barry M. Trost, Kalindi Dogra, Iwao Hachiya, +7

Angewandte Chemie International Edition

Efficient Asymmetric Synthesis of Novel Gastrin Receptor Antagonist AG-041R via Highly Stereoselective Alkylation of Oxindole Enolates

Takashi Emura, Toru Esaki, Kazutaka Tachibana, +1

The Journal of Organic Chemistry

Medicinal ChemistryEnantioselective SynthesisCore Oxindole StereochemistryNatural SciencesMedicine +11

Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment

Akie Homma, Haruhiko Sato, Akira Okamachi, +21

Bioorganic & Medicinal Chemistry

Regenerative MedicineRheumatologyMedicineOsteoarthritisPharmacology +3

Asymmetric aldol reaction of α-ketoesters with isocyanoacetate and isocyanoacetamide catalyzed by a chiral ferrocenylphosphine-gold(I) complex

Yoshihiko Ito, Masaya Sawamura, Hitoshi Hamashima, +2

Tetrahedron Letters

EngineeringBiochemistryNatural SciencesOrganic ChemistryOrganometallic Catalysis +5

Synthesis and optimization of hyaluronic acid–methotrexate conjugates to maximize benefit in the treatment of osteoarthritis

Akie Homma, Haruhiko Sato, Tatsuya Tamura, +21

Bioorganic & Medicinal Chemistry

Musculoskeletal ResearchPolymer-drug ConjugateMedicineOsteoarthritisHyaluronic Acid–methotrexate Conjugates +3

Discovery of novel tetracyclic compounds as anaplastic lymphoma kinase inhibitors

Kazutomo Kinoshita, Yoshiyuki Ono, Takashi Emura, +10

Bioorganic & Medicinal Chemistry Letters

MedicineNovel Tetracyclic CompoundsAnti-cancer AgentDrug DevelopmentPharmacology +2

Development of a Scalable Synthesis of Tofogliflozin

Yoshihito Ohtake, Takashi Emura, Masahiro Nishimoto, +10

The Journal of Organic Chemistry

Medicinal ChemistryPharmaceutical ScienceBioorganic ChemistryBiochemistryMedicine +13

Lead Optimization and Avoidance of Reactive Metabolite Leading to PCO371, a Potent, Selective, and Orally Available Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist

Yoshikazu Nishimura, Toru Esaki, Yoshiaki Isshiki, +14

Journal of Medicinal Chemistry

Design and synthesis of an androgen receptor pure antagonist (CH5137291) for the treatment of castration-resistant prostate cancer

Hitoshi Yoshino, Haruhiko Sato, Takuya Shiraishi, +14

Bioorganic & Medicinal Chemistry

UrologyOncologyMedicinePharmacotherapyCastration-resistant Prostate Cancer +5