Don J. Mahuran

Identification and Characterization of Ambroxol as an Enzyme Enhancement Agent for Gaucher Disease

Gustavo Maegawa, Michael B. Tropak, Justin Buttner et al. · Journal of Biological Chemistry · 2009 · 332 citations · Full text

Life Sciences, Biochemistry, Pharmacology +15

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

Stephen Pasternak, Richard D. Bagshaw, Marianne Guiral et al. · Journal of Biological Chemistry · 2003 · 309 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins

Dapeng Zhou, Carlos Cantu, Yuval Sagiv et al. · Science · 2003 · 309 citations · Full text

Life Sciences, Immunology, Molecular Biology +15

Crystal Structure of Human β-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay–Sachs Disease

Brian L. Mark, Don J. Mahuran, M.M. Cherney et al. · Journal of Molecular Biology · 2003 · 225 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients

Michael B. Tropak, Stephen P. Reid, Marianne Guiral et al. · Journal of Biological Chemistry · 2004 · 200 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17