Alanna M. Harden

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

S Ziemin-van der Poel, Norah R. McCabe, Heidi J. Gill et al. · Proceedings of the National Academy of Sciences · 1991 · 594 citations · Full text

Hematological Malignancy, Chromatin, Medicine +15

MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)

Olatoyosi M. Sobulo, Julian Borrow, R Tomek et al. · Proceedings of the National Academy of Sciences · 1997 · 324 citations · Full text

Histone Modifications, Mixed-phenotype Acute Leukemia, Epigenetic Change +22

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

Nancy J. Zeleznik‐Le, Alanna M. Harden, Janet D. Rowley · Proceedings of the National Academy of Sciences · 1994 · 233 citations

Deletions of Interferon Genes in Acute Lymphoblastic Leukemia

Manuel O. Dı́az, Charles M. Rubin, Alanna M. Harden et al. · New England Journal of Medicine · 1990 · 215 citations · Full text

Establishment and characterization of a megakaryoblast cell line with amplification of MLL

RJ Allen, SD Smith, RL Moldwin et al. · Leukemia · 1998 · 47 citations

Cell Division, Molecular Biology, Cell Culture +5