Anirudha Lakshminarasimhan

PD-1 derived CA-170 is an oral immune checkpoint inhibitor that exhibits preclinical anti-tumor efficacy

Pottayil G. Sasikumar, Naremaddepalli S. Sudarshan, Srinivas Adurthi et al. · Communications Biology · 2021 · 144 citations · Full text

Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors

Mohamed Takhi, Kandepu Sreenivas, Chandrashekar K. Reddy et al. · European Journal of Medicinal Chemistry · 2014 · 33 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +9

Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode

Venkateshwar Rao Gummadi, Sujatha Rajagopalan, Chung Yeng Looi et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 22 citations · Full text

Drug Target, Wild Type, Medicine +9

Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors

Rajeev Goswami, Gerd Wohlfahrt, Olli Törmäkangas et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 13 citations · Full text

Medicinal Chemistry, Biochemistry, Natural Sciences +10

<scp>AFN</scp>‐1252 is a potent inhibitor of enoyl‐<scp>ACP</scp>reductase from<scp><i>B</i></scp><i>urkholderia pseudomallei</i>—Crystal structure, mode of action, and biological activity

K.N. Rao, Anirudha Lakshminarasimhan, Sarah Joseph et al. · Protein Science · 2015 · 12 citations · Full text

Potent Inhibitor, Molecular Biology, Antimicrobial Chemotherapy +25