A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Bramwell G. Lambrus, Vikas Daggubati, Yumi Uetake, +4

The Journal of Cell Biology

ChromatinGenome InstabilityCentrosome LossCell RegulationCell Division +13

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

Tyler C. Moyer, Kevin M. Clutario, Bramwell G. Lambrus, +2

The Journal of Cell Biology

p53 protects against genome instability following centriole duplication failure

Bramwell G. Lambrus, Yumi Uetake, Kevin M. Clutario, +4

The Journal of Cell Biology

Genome InstabilityDevelopmental BiologyCell DivisionGeneticsGenomic Mechanism +13

Superenhancer activation of KLHDC8A drives glioma ciliation and hedgehog signaling

Derrick Lee, Ryan C. Gimple, Xujia Wu, +9

Journal of Clinical Investigation

Vivo Tumor GrowthDevelopmental BiologyHedgehog SignalingGliomaEpigenetic Regulation +11

Sterol and oxysterol synthases near the ciliary base activate the Hedgehog pathway

Sarah Findakly, Vikas Daggubati, Galo García, +10

The Journal of Cell Biology

EngineeringCiliary BasePrimary CiliumCellular PhysiologyBiosynthesis +18

Smoothened-activating lipids drive resistance to CDK4/6 inhibition in Hedgehog-associated medulloblastoma cells and preclinical models

Vikas Daggubati, Jordan Hochstelter, Anirudh Bommireddy, +8

Journal of Clinical Investigation

Cdk6 InhibitionImmunologyEr StressCancer BiologyCellular Physiology +19

Clinical Applications of Quantitative 3-Dimensional MRI Analysis for Pediatric Embryonal Brain Tumors

Jared H. Hara, Ashley Wu, Javier Villanueva-Meyer, +7

International Journal of Radiation Oncology*Biology*Physics

Neuro-oncologyPediatric Brain TumorsEngineeringMedical ImagingPet-mri +12

Multiplatform Molecular Profiling Reveals Epigenomic Intratumor Heterogeneity in Ependymoma

Siyuan Liu, Stephen T. Magill, Harish N. Vasudevan, +16

Cell Reports

Somatic VariantTumor HeterogeneityDistinct Genetic SubgroupsGeneticsDna Methylation +12

Meningioma cells express primary cilia but do not transduce ciliary Hedgehog signals

Sarah Findakly, Abrar Choudhury, Vikas Daggubati, +3

Acta Neuropathologica Communications