John J. Acton

Benzoyl 2-methyl indoles as selective PPARγ modulators

John J. Acton, Regina M. Black, A. Brian Jones et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 130 citations · Full text

Molecular Pharmacology, Functional Selectivity, Medicine +4

Selective PPARγ modulators with improved pharmacological profiles

Kun Liu, Regina M. Black, John J. Acton et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 62 citations · Full text

Molecular Pharmacology, G Protein-coupled Receptor, Medicine +6

(±)- Trans -2-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist

Mitree M. Ponpipom, San-Bao Hwang, Thomas W. Doebber et al. · Biochemical and Biophysical Research Communications · 1988 · 58 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Science +10

Discovery of (2<i>R</i>)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1<i>H</i>-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment of Type 2 Diabetes Mellitus with a Reduced Potential to Increase Plasma and Extracellular Fluid Volume

John J. Acton, Taro E. Akiyama, Ching H. Chang et al. · Journal of Medicinal Chemistry · 2009 · 52 citations · Full text

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar et al. · Journal of Medicinal Chemistry · 2021 · 40 citations · Full text