Melanie C. Zigler

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

Vienna E. Brunt, Rachel A. Gioscia‐Ryan, Abigail G. Casso et al. · Hypertension · 2020 · 270 citations · Full text

Education, Nutritional Sciences, Pharmacology +17

Mitochondria‐targeted antioxidant (MitoQ) ameliorates age‐related arterial endothelial dysfunction in mice

Rachel A. Gioscia‐Ryan, Thomas J. LaRocca, Amy L. Sindler et al. · The Journal of Physiology · 2014 · 257 citations · Full text

Life Sciences, Cell Biology, Geriatric Medicine +17

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

Vienna E. Brunt, Rachel A. Gioscia‐Ryan, James J. Richey et al. · The Journal of Physiology · 2019 · 177 citations · Full text

Life Sciences, Cardiology, Microbiology +17

Dietary rapamycin supplementation reverses age‐related vascular dysfunction and oxidative stress, while modulating nutrient‐sensing, cell cycle, and senescence pathways

Lisa A. Lesniewski, Douglas R. Seals, Ashley E. Walker et al. · Aging Cell · 2016 · 166 citations · Full text

Education, Biochemistry, Pharmacology +17

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans

Vienna E. Brunt, Abigail G. Casso, Rachel A. Gioscia‐Ryan et al. · Hypertension · 2021 · 95 citations · Full text

Life Sciences, Cardiology, Microbiology +17