Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer

Namrata S. Patil, Barzin Y. Nabet, Sören Müller, +18

Cancer Cell

Intratumoral Plasma CellsCancer ImmunosurveillancePd-l1 BlockadeMedicineImmunology +6

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

Jason Cheng, Hongyun She, Yuan‐Ping Han, +4

American Journal of Physiology-Gastrointestinal and Liver Physiology

Liver FibrosisImmunologyPathologyFatty Liver DiseaseCholangiopathies +24

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

Mallika Singh, Anthony Lima, Rafael Molina, +17

Nature Biotechnology

Knockout MouseTumor BiologyTransgenic Mouse ModelsTumor HeterogeneityKras Mutant Cancers +9

Steatohepatitis Induced by Intragastric Overfeeding in Mice *

Qing-gao Deng, Hongyun She, Jason Cheng, +4

Hepatology

PKC-δ and -ε regulate NF-κB activation induced by cholecystokinin and TNF-α in pancreatic acinar cells

Akihiko Satoh, Anna S. Gukovskaya, José Nieto, +5

American Journal of Physiology-Gastrointestinal and Liver Physiology

ImmunologyImmune RegulationPathologyCellular PhysiologyInflammation +18

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Snahel Patel, Joshua D. Webster, Eugene Varfolomeev, +22

Cell Death and Differentiation

ImmunologyPathologyCell DeathKinase Rip1Cancer Biology +14

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

Vernon T. Phan, Xiumin Wu, Jason Cheng, +13

Proceedings of the National Academy of Sciences

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

Mark Merchant, John G. Moffat, Gabriele Schaefer, +20

PLoS ONE

Erk InhibitionCancer BiologyBraf Mutant ModelsTumor BiologySignaling Pathway +14

Phosphatidylinositide 3-kinase γ regulates key pathologic responses to cholecystokinin in pancreatic acinar cells

Ilya Gukovsky, Jason Cheng, Kyung Jin Nam, +6

Gastroenterology

Signal TransductionSignaling PathwayPancreatic CancerCell RegulationImmunology +9

A rat model reproducing key pathological responses of alcoholic chronic pancreatitis

Ilya Gukovsky, Aurelia Lugea, Mohammad Shahsahebi, +9

American Journal of Physiology-Gastrointestinal and Liver Physiology

InflammationChronic PancreatitisAnti-inflammatoryKey Pathological ResponsesMedicine +13