1b:I[76749,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 1c:I[3486,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 1d:I[41892,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 1e:I[17707,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 1f:I[66528,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 20:I[63176,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 21:I[87099,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 22:I[26200,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"Group"] 23:I[23365,["/_next/static/chunks/f9f65a69b09cd00d.js","/_next/static/chunks/1ba21a8e081e29d1.js","/_next/static/chunks/0383663887945ae7.js","/_next/static/chunks/5bf36002c846d2d8.js","/_next/static/chunks/63561dcd578bd4db.js","/_next/static/chunks/29d2646804fd1cab.js","/_next/static/chunks/2060b26370dc6c0a.js"],"default"] 24:T519,A new series of coumarin derivatives, 7-hydroxy-7-(trifluoromethyl)-6a,12b-dihydro-6H,7H-chromeno[3,4-c]chromen-6-ones 3a-p, were synthesized via Michael addition, transesterification and nucleophilic addition from the reaction of 3-trifluoroacetyl coumarins and phenols in the presence of an organic base. The products were characterized by infrared spectroscopy (IR), hydrogen nuclear magnetic resonance spectroscopy (¹H-NMR), carbon nuclear magnetic resonance spectroscopy (¹³C-NMR) and high-resolution mass spectrometer (HRMS). Single crystal X-ray analysis of compounds 3a and 3n clearly confirmed their assigned chemical structures and their twisted conformations. Compound 3a crystallized in the orthorhombic system, Pbca, in which a = 8.6244(2) Å, b = 17.4245(4) Å, c = 22.5188(6) Å, α = 90°, β = 90°, γ = 90°, v = 3384.02(14) Å³, and z = 8. In addition, the mycelial growth rate method was used to examine the in vitro antifungal activities of the title compounds 3a-p against Fusarium graminearum and Fusarium monitiforme at 500 µg/mL.

Jin-Ping Bao

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