Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

P. Rusmini, Katia Cortese, V. Crippa, +13

Autophagy

Motoneuron DegenerationMitophagyCell DeathCellular PhysiologyCell Autophagy +18

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

V. Crippa, D. Sau, P. Rusmini, +10

Human Molecular Genetics

Hspb8 ExpressionCell DeathMolecular BiologyProteasome ActivityProtein Folding +14

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

V. Crippa, Vito D’Agostino, Riccardo Cristofani, +12

Scientific Reports

The small heat shock protein B8 (HSPB8) efficiently removes aggregating species of dipeptides produced in C9ORF72-related neurodegenerative diseases

Riccardo Cristofani, V. Crippa, G. Vezzoli, +10

Cell Stress and Chaperones

Type 1 astrocytes influence luteinizing hormone-releasing hormone release from the hypothalamic cell line GT1-1: is transforming growth factor-beta the principle involved?

Roberto Cosimo Melcangi, M. Galbiati, Elio Messi, +3

Endocrinology

Inhibition of retrograde transport modulates misfolded protein accumulation and clearance in motoneuron diseases

Riccardo Cristofani, V. Crippa, P. Rusmini, +12

Autophagy

MitophagyCell DeathMolecular BiologyCytoskeletonActive Retrograde Transport +24

Tdp-25 Routing to Autophagy and Proteasome Ameliorates its Aggregation in Amyotrophic Lateral Sclerosis Target Cells

M.E. Cicardi, Riccardo Cristofani, P. Rusmini, +11

Scientific Reports

MitophagyCell DeathMolecular BiologyProteasome AmelioratesCell Autophagy +15

Transforming growth factor-beta and astrocytic conditioned medium influence luteinizing hormone-releasing hormone gene expression in the hypothalamic cell line GT1.

M. Galbiati, M. Zanisi, Elio Messi, +3

Endocrinology

Human GrowthCellular PhysiologySocial SciencesType 1Neuroendocrine Mechanism +17

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis

Elisa Onesto, P. Rusmini, V. Crippa, +4

Journal of Neurochemistry

Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy

P. Rusmini, María José Polanco, Riccardo Cristofani, +13

Scientific Reports