Chao J. Wang

Small-molecule inhibitors targeting the DNA-binding domain of STAT3 suppress tumor growth, metastasis and STAT3 target gene expression in vivo

Wenbin Huang, Zhen Dong, Yen‐Shan Chen et al. · Oncogene · 2015 · 107 citations

Drug Targeting, Medicine, Small Molecules +9

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1

Xi Wu, Zizheng Dong, Chao J. Wang et al. · Proceedings of the National Academy of Sciences · 2016 · 91 citations · Full text

Chemoprevention Strategy, Parp-1 Expression, Apoptosis +27

Proton pump inhibitors suppress DNA damage repair and sensitize treatment resistance in breast cancer by targeting fatty acid synthase

Chao J. Wang, Deren Li, Jacob A. Danielson et al. · Cancer Letters · 2021 · 53 citations · Full text

Breast Oncology, Biochemistry, Proton Pump Inhibitors +6

Initial Phase I Safety Study of Gedatolisib plus Cofetuzumab Pelidotin for Patients with Metastatic Triple-Negative Breast Cancer

Milan Radovich, Jeffrey P. Solzak, Chao J. Wang et al. · Clinical Cancer Research · 2022 · 27 citations · Full text

Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase

Jenny Beebe, Sophia Josephraj, Chao J. Wang et al. · Journal of Medicinal Chemistry · 2022 · 12 citations · Full text

Medicinal Chemistry, Biochemistry, Fatty Acid Synthase +15