Susan M. Cusick

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections

Bin Liu, Robert E. Lee Trout, Guo‐Hua Chu et al. · Journal of Medicinal Chemistry · 2019 · 298 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in <i>Enterobacterales</i> and Pseudomonas aeruginosa

Jodie C. Hamrick, Jean‐Denis Docquier, Tsuyoshi Uehara et al. · Antimicrobial Agents and Chemotherapy · 2019 · 213 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17

<i>In Vitro</i> Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program

James A. Karlowsky, Meredith Hackel, Mark G. Wise et al. · Antimicrobial Agents and Chemotherapy · 2022 · 70 citations · Full text

Life Sciences, Infectious Diseases, Microbiology +17

Discovery of VNRX-7145 (VNRX-5236 Etzadroxil): An Orally Bioavailable β-Lactamase Inhibitor for Enterobacterales Expressing Ambler Class A, C, and D Enzymes

Robert E. Lee Trout, Allison L. Zulli, Eugen F. Mesaros et al. · Journal of Medicinal Chemistry · 2021 · 47 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of <i>Enterobacterales</i> Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases

Cassandra L. Chatwin, Jodie C. Hamrick, Robert E. Lee Trout et al. · Antimicrobial Agents and Chemotherapy · 2021 · 35 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +16