LC–MS/MS-Based Quantification of Kynurenine Metabolites, Tryptophan, Monoamines and Neopterin in Plasma, Cerebrospinal Fluid and Brain

René Fuertig, Angelo Ceci, Sandrine Camus, +3

Bioanalysis

Neurochemical BiomarkersPre-clinical PharmacologyMolecular PharmacologyCerebrospinal FluidBioanalysis +18

Mouse chronic social stress increases blood and brain kynurenine pathway activity and fear behaviour: Both effects are reversed by inhibition of indoleamine 2,3-dioxygenase

René Fuertig, Damiano Azzinnari, Giorgio Bergamini, +8

Brain Behavior and Immunity

PsychoneuroimmunologyStress HormonePsychiatryBehavioral NeuroscienceAffective Neuroscience +6

Two first-in-human studies of xentuzumab, a humanised insulin-like growth factor (IGF)-neutralising antibody, in patients with advanced solid tumours

Johann S. de Bono, Chia‐Chi Lin, Li‐Tzong Chen, +20

British Journal of Cancer

Differential effects of peripheral and brain tumor necrosis factor on inflammation, sickness, emotional behavior and memory in mice

Federica Klaus, Jean‐Charles Paterna, Elisa Marzorati, +10

Brain Behavior and Immunity

InflammationPsychoneuroimmunologyEmotional BehaviorDifferential EffectsMedicine +9

CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway

Flurin Cathomas, René Fuertig, Hannes Sigrist, +10

Brain Behavior and Immunity

Cd40-tnf ActivationAutoimmune DiseaseDisease MechanismMedicineImmune Regulation +7

The effects of transient receptor potential cation channel inhibition by BI 1358894 on cortico-limbic brain reactivity to negative emotional stimuli in major depressive disorder

Simone Grimm, Christian Keicher, Christian Paret, +13

European Neuropsychopharmacology

A novel liquid chromatography/tandem mass spectrometry method for the quantification of glycine as biomarker in brain microdialysis and cerebrospinal fluid samples within 5min

Patrizia Voehringer, René Fuertig, Boris Ferger

Journal of Chromatography B

BiochemistryMedicineNatural SciencesBioanalysisMass Spectrometry +9

Phase I dose‐escalation study of volasertib in pediatric patients with acute leukemia or advanced solid tumors

François Doz, Franco Locatelli, André Baruchel, +10

Pediatric Blood & Cancer

Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males

Markus Goettel, René Fuertig, Salome Rebecca Mack, +4

CNS Drugs

Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies

René Fuertig, Markus Goettel, Lena Herich, +3

CNS Drugs