J.M. Brugge

Impaired APC cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations

Elisabetta Castoldi, J.M. Brugge, Gerry A. F. Nicolaes et al. · Blood · 2004 · 97 citations · Full text

Life Sciences, Genetics, Molecular Genetics +11

Protein S levels modulate the activated protein C resistance phenotype induced by elevated prothrombin levels

J.M. Brugge, Guido Tans, Jan Rosing et al. · Thrombosis and Haemostasis · 2006 · 24 citations

Medicine, Biochemistry, Hematology +17

Theoretical and Experimental Study of the D2194G Mutation in the C2 Domain of Coagulation Factor V

Maria A. Miteva, J.M. Brugge, Jan Rosing et al. · Biophysical Journal · 2004 · 22 citations · Full text

Medicine, Biochemistry, Genetics +17