Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

Hyejung Won, Hye‐Ryeon Lee, Heon Yung Gee, +15

Nature

Shank2-mutant MiceNmda Receptor FunctionAutistic-like Social BehaviourBehavioral SciencesBehavioral Neuroscience +7

Shank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit

Jiseok Lee, Changuk Chung, Seungmin Ha, +4

Frontiers in Cellular Neuroscience

Brain DevelopmentSynaptic TransmissionNeurotransmissionCellular NeurobiologySynaptic Signaling +16

Sexually dimorphic behavior, neuronal activity, and gene expression in Chd8-mutant mice

Hwajin Jung, Haram Park, Yeonsoo Choi, +26

Nature Neuroscience

Knockout MouseMolecular NeuroscienceDevelopmental BiologyBehavioral NeuroscienceMedicine +11

Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors

Seungmin Ha, Dong‐Won Lee, Yi Sul Cho, +9

Journal of Neuroscience

Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation

Eun‐Jae Lee, Hyejin Lee, Tzyy‐Nan Huang, +6

Nature Communications

Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development

Changuk Chung, Xiaoxu Yang, Taejeong Bae, +89

Nature Genetics

Developmental AnomalyDevelopmental BiologySomatic MutationsSomatic VariantGenetic Disorder +8

Cell-Type-Specific<i>Shank2</i>Deletion in Mice Leads to Differential Synaptic and Behavioral Phenotypes

Ryunhee Kim, Jihye Kim, Changuk Chung, +7

Journal of Neuroscience

Early Correction of N-Methyl-D-Aspartate Receptor Function Improves Autistic-like Social Behaviors in Adult Shank2−/− Mice

Changuk Chung, Seungmin Ha, Hyojin Kang, +26

Biological Psychiatry

Behavioral SciencesMolecular NeuroscienceSocial SkillsBehavioral NeuroscienceBrain Development +12

Somatic mosaicism reveals clonal distributions of neocortical development

Martin W. Breuss, Xiaoxu Yang, Johannes C. M. Schlachetzki, +20

Nature

Developmental BiologyBrain StructureDevelopmental Cognitive NeuroscienceNeuroanatomyCortical Remodeling +7

A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion

Guoliang Chai, Emmanuelle Szenker‐Ravi, Changuk Chung, +27

New England Journal of Medicine