Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies

James Sharpe, Ulf Ahlgren, Paul Perry, +5

Science

β-Cell-specific inactivation of the mouse<i>Ipf1/Pdx1</i> gene results in loss of the β-cell phenotype and maturity onset diabetes

Ulf Ahlgren, Jörgen Jönsson, Lena Jönsson, +2

Genes & Development

Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells

Ulf Ahlgren, Samuel L. Pfaff, Thomas M. Jessell, +1

Nature

Signal TransductionPancreatic CancerImmunologyIndependent RequirementPancreatic Mesenchyme +6

The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice

Ulf Ahlgren, Jan‐Ingvar Jönsson, Helena Edlund

Development

Organ DevelopmentCellular PhysiologyInsulin SignalingEmbryologyTissue Development +17

Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas

Åsa Apelqvist, Ulf Ahlgren, Helena Edlund

Current Biology

Mesoderm DifferentiationSonic Hedgehog DirectsDevelopmental BiologyPhysiologyGastroenterology +6

Tomographic molecular imaging and 3D quantification within adult mouse organs

Tomas Alanentalo, Amir Asayesh, Harris Morrison, +4

Nature Methods

Tomographic Molecular ImagingTissue ImagingEngineeringMedical ImagingNovel Imaging Method +10

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Luc Baeyens, M. Lemper, Gunter Leuckx, +18

Nature Biotechnology

InflammationCytokineDiabetesCell ReprogrammingImmunology +8

Nuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion

Stefan Norlin, Ulf Ahlgren, Helena Edlund

Diabetes

The splanchnic mesodermal plate directs spleen and pancreatic laterality,and is regulated by <i>Bapx1/Nkx3.2</i>

Jacob Hecksher‐Sørensen, Robert P. Watson, Laura A. Lettice, +5

Development

Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

Mark Van de Casteele, G. Leuckx, Luc Baeyens, +13

Cell Death and Disease