James B. Koprich

Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV α-Synucleinopathy

Chee Yeun Chung, James B. Koprich, Hasan K. Siddiqi et al. · Journal of Neuroscience · 2009 · 379 citations · Full text

Rabphilin 3A, Synaptic Transmission, Significant Dopaminergic +21

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

James B. Koprich, Casper Reske-Nielsen, Prabhakar Mithal et al. · Journal of Neuroinflammation · 2008 · 323 citations · Full text

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

Chi Wang Ip, Laura-Christin Klaus, Akua A. Karikari et al. · Acta Neuropathologica Communications · 2017 · 169 citations · Full text

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

James B. Koprich, Tom H. Johnston, M. Gabriela Reyes et al. · Molecular Neurodegeneration · 2010 · 144 citations · Full text

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

Chris McKinnon, Mitchell L. de Snoo, Elise Gondard et al. · Acta Neuropathologica Communications · 2020 · 132 citations · Full text