Chitra M. Vaidya

Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor <i>N</i>^α-(4-Amino-4-deoxypteroyl)-<i>N</i>^δ-hemiphthaloyl-<scp>l</scp>-ornithine (PT523)

A. Rosowsky, Joel E. Wright, Chitra M. Vaidya et al. · Journal of Medicinal Chemistry · 1998 · 27 citations · Full text

Pharmaceutical Science, Bioorganic Chemistry, Potent Antifolate Activity +17

Analogues of the Potent Nonpolyglutamatable Antifolate <i>N</i>^α-(4-Amino-4-deoxypteroyl)-<i>N</i>^δ-hemiphthaloyl-<scp>l</scp>-ornithine (PT523) with Modifications in the Side Chain, <i>p</i>-Aminobenzoyl Moiety, or 9,10-Bridge:  Synthesis and in Vitro Antitumor Activity

A. Rosowsky, Joel E. Wright, Chitra M. Vaidya et al. · Journal of Medicinal Chemistry · 2000 · 22 citations

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523) and its B-ring analogues

Joel E. Wright, Chitra M. Vaidya, Yingnan Chen et al. · Biochemical Pharmacology · 2000 · 22 citations

Hematological Malignancy, Reduced Folate Carrier, Medicine +6

Analogues of <i>N</i>^α-(4-Amino-4-deoxypteroyl)-<i>N</i>^δ-hemiphthaloyl-<scp>l</scp>-ornithine (PT523) Modified in the Side Chain:  Synthesis and Biological Evaluation

A. Rosowsky, Chitra M. Vaidya, Henry Bader et al. · Journal of Medicinal Chemistry · 1997 · 20 citations

Synthesis and In Vitro Antitumor Activity of New Deaza Analogues of the Nonpolyglutamatable Antifolate<i>N</i>^α-(4-Amino-4-deoxypteroyl)-<i>N</i>^δ-hemiphthaloyl-<scp>l</scp>-ornithine (PT523)

Chitra M. Vaidya, Joel E. Wright, A. Rosowsky · Journal of Medicinal Chemistry · 2002 · 13 citations · Full text