Theo Botella

Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells

Claudia Capdevila, Jonathan Miller, Liang Cheng et al. · Cell · 2024 · 68 citations · Full text

Cell Lineage, Signal Transduction, Time-resolved Fate Mapping +7

Multiplexed single-cell analysis reveals prognostic and nonprognostic T cell types in human colorectal cancer

Kazuya Masuda, Adam Kornberg, Jonathan Miller et al. · JCI Insight · 2022 · 60 citations · Full text

T-regulatory Cell, Immunology, Pathology +19

Mapping genotypes to chromatin accessibility profiles in single cells

Franco Izzo, Robert M. Myers, Saravanan Ganesan et al. · Nature · 2024 · 51 citations · Full text

Chromatin, Chromatin Remodeling, Genetics +7

Gluten induces rapid reprogramming of natural memory αβ and γδ intraepithelial T cells to induce cytotoxicity in celiac disease

Adam Kornberg, Theo Botella, Christine S. Moon et al. · Science Immunology · 2023 · 42 citations · Full text

Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome

Saravanan Ganesan, Rebecca M. Murray, Jesús Alfonso López Sotélo et al. · 2024 · 11 citations · Full text