Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Yuto Unoh, Shota Uehara, Kenji Nakahara, +22

Journal of Medicinal Chemistry

Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly

Naoya Sawamura, T Ando, Yuki Maruyama, +16

Molecular Psychiatry

BiologySleep HomeostasisTranscriptional RegulationFruit FlyDevelopmental Biology +8

Developmentally-Regulated Excision of the SPβ Prophage Reconstitutes a Gene Required for Spore Envelope Maturation in Bacillus subtilis

Kimihiro Abe, Yuta Kawano, Keito Iwamoto, +4

PLoS Genetics

Microbial PathogensGeneticsBacteriologyBacteriophageMolecular Biology +19

S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters

Michihito Sasaki, Koshiro Tabata, Mai Kishimoto, +19

Science Translational Medicine

Discovery of S-217622, a Non-Covalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

Yuto Unoh, Shota Uehara, Kenji Nakahara, +22

Coronavirus Disease 2019Molecular PharmacologyMedicinal ChemistryVirtual ScreeningMedicine +13

Coding sequence of human placenta Cofilin cDNA

Kazunori Ogawa, Masarou Tashima, Y Yumoto, +4

Nucleic Acids Research

Reproductive SciencesGeneticsPathologyMolecular GeneticsEmbryology +14

Gene expression and molecular characterization of a novel C-type lectin, encapsulation promoting lectin (EPL), in the rice armyworm, Mythimna separata

Teruhito Ishihara, Yuki Maruyama, Seiichi Furukawa

Insect Biochemistry and Molecular Biology

BiologyRice ArmywormNatural SciencesGeneticsGenetic Engineering +5

Exploration and Grading of Possible Genes from 183 Bacterial Strains by a Common Protocol to Identification of New Genes: Gene Trek in Prokaryote Space (GTPS)

Takehide Kosuge, Takashi Abe, Toshihisa Okido, +12

DNA Research

The Effect of Changing the Contraction Mode During Resistance Training on mTORC1 Signaling and Muscle Protein Synthesis

Satoru Ato, Daisuke Tsushima, Yurie Isono, +4

Frontiers in Physiology

High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis

Yuki Maruyama, Chisaki Ikeda, Koki Wakabayashi, +2

Journal of Applied Physiology