SAR Exploration Guided by LE and Fsp ³ : Discovery of a Selective and Orally Efficacious RORγ Inhibitor

Kazuyuki Hirata, Masayuki Kotoku, Noriyoshi Seki, +29

ACS Medicinal Chemistry Letters

The effect of oxysterols on the interaction of Alzheimer's amyloid beta with model membranes

Huong T.T. Phan, Takahiro Hata, Masamune Morita, +4

Biochimica et Biophysica Acta (BBA) - Biomembranes

Alzheimer's DiseaseOxysterolBiochemistryNeurochemical BiomarkersProtein Misfolding +6

JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Suppresses Food Intake and Gastric Emptying with the Elevation of Plasma Peptide YY and Glucagon-Like Peptide-1 in a Dietary Fat-Dependent Manner

Takahiro Hata, Yasuko Mera, Yukihito Ishii, +6

Journal of Pharmacology and Experimental Therapeutics

Selective localization of Alzheimer's amyloid beta in membrane lateral compartments

Masamune Morita, Tsutomu Hamada, Yuiko Tendo, +3

Soft Matter

Proteinlipid InteractionAlzheimer's DiseaseMembrane BiophysicsBiochemistryProtein Folding +13

Pharmacological Characterization of Diethyl-2-({3-dimethylcarbamoyl-4-[(4′-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT-130), an Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein

Yasuko Mera, Naoya Odani, Takashi Kawai, +5

Journal of Pharmacology and Experimental Therapeutics

Pathophysiological Analysis of Female Spontaneously Diabetic Torii Fatty Rats

Yukihito Ishii, Takeshi Ohta, Tomohiko Sasase, +9

EXPERIMENTAL ANIMALS

ObesityMetabolic SyndromeSdt-fa/fa RatsUrologyBody Composition +13

A high-fat diet inhibits the progression of diabetes mellitus in type 2 diabetic rats

Yukihito Ishii, Takeshi Ohta, Tomohiko Sasase, +8

Nutrition Research

ObesityMetabolic SyndromeNutritionBody CompositionDiabetes +8

JTT‐130, a novel intestine‐specific inhibitor of microsomal triglyceride transfer protein, ameliorates impaired glucose and lipid metabolism in Zucker diabetic fatty rats

Takahiro Hata, Yasuko Mera, Takashi Kawai, +5

Diabetes Obesity and Metabolism

JTT‐130, a novel intestine‐specific inhibitor of microsomal triglyceride transfer protein, suppresses high fat diet‐induced obesity and glucose intolerance in Sprague‐Dawley rats

Takahiro Hata, Yasuko Mera, Hironobu Tadaki, +4

Diabetes Obesity and Metabolism

Pharmacological Properties of JTE-952, an Orally Available and Selective Colony Stimulating Factor 1 Receptor Kinase Inhibitor

Naofumi Uesato, Naoki Miyagawa, Koji Inagaki, +7

Biological and Pharmaceutical Bulletin

ImmunologyMarked Inhibitory ActivityPharmacotherapySignaling PathwayReceptor Tyrosine Kinase +15