Alexandre Esadze

Balancing between affinity and speed in target DNA search by zinc-finger proteins via modulation of dynamic conformational ensemble

Levani Zandarashvili, Alexandre Esadze, Dana Vuzman et al. · Proceedings of the National Academy of Sciences · 2015 · 111 citations · Full text

Asymmetrical roles of zinc fingers in dynamic DNA-scanning process by the inducible transcription factor Egr-1

Levani Zandarashvili, Dana Vuzman, Alexandre Esadze et al. · Proceedings of the National Academy of Sciences · 2012 · 103 citations · Full text

Dynamics of Lysine Side-Chain Amino Groups in a Protein Studied by Heteronuclear ¹H−¹⁵N NMR Spectroscopy

Alexandre Esadze, Dawei Li, Tianzhi Wang et al. · Journal of the American Chemical Society · 2010 · 77 citations

Molecular Biology, Molecular Dynamics, Protein Folding +17

Positive and negative impacts of nonspecific sites during target location by a sequence-specific DNA-binding protein: origin of the optimal search at physiological ionic strength

Alexandre Esadze, Catherine A. Kemme, Anatoly B. Kolomeisky et al. · Nucleic Acids Research · 2014 · 71 citations · Full text

Biophysical Modeling, Molecular Biology, Optimal Search +16

Direct Observation of the Ion-Pair Dynamics at a Protein–DNA Interface by NMR Spectroscopy

Kurtis M. Anderson, Alexandre Esadze, Mariappan Manoharan et al. · Journal of the American Chemical Society · 2013 · 61 citations · Full text

Protein Chemistry, Single Molecule Biophysics, Nmr Spectroscopy +15