R. Matthew Weekly

Orally-Effective, Long-Acting Sorbitol Dehydrogenase Inhibitors:  Synthesis, Structure−Activity Relationships, and in Vivo Evaluations of Novel Heterocycle-Substituted Piperazino-Pyrimidines

Margaret Y. Chu‐Moyer, William E. Ballinger, David A. Beebe et al. · Journal of Medicinal Chemistry · 2001 · 48 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Synthesis of Nirmatrelvir: Development of a Scalable Cobalt-Catalyzed Cyclopropanation for Manufacture of the Bicyclic [3.1.0]Proline-Building Block

Russell F. Algera, Christophe Allais, Aaron F. Baldwin et al. · Organic Process Research & Development · 2023 · 22 citations

Natural Sciences, Chemistry, Medicinal Chemistry +17

Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment

Russell F. Algera, Christophe Allais, Aaron F. Baldwin et al. · Organic Process Research & Development · 2023 · 16 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14

Synthesis of Nirmatrelvir: Design and Optimization of an Efficient Telescoped Amidation–Dehydration Sequence

Russell F. Algera, Aaron F. Baldwin, Paul Bowles et al. · Organic Process Research & Development · 2023 · 15 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15

Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment

Russell F. Algera, Christophe Allais, Husein Becirovic et al. · Organic Process Research & Development · 2023 · 14 citations

Pharmacy, Chemistry, Medicinal Chemistry +14