Joel A. Cummings

Perlecan Binds to the β‐Amyloid Proteins (Aβ) of Alzheimer's Disease, Accelerates Aβ Fibril Formation, and Maintains Aβ Fibril Stability

Gerardo M. Castillo, Catherine Ngo, Joel A. Cummings et al. · Journal of Neurochemistry · 1997 · 256 citations

Sulfate content and specific glycosaminoglycan backbone of perlecan are critical for perlecan's enhancement of islet amyloid polypeptide (amylin) fibril formation.

Gerardo M. Castillo, Joel A. Cummings, Wen Yang et al. · Diabetes · 1998 · 130 citations

The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago

Alan D. Snow, Joel A. Cummings, Thomas P. Lake · Frontiers in Aging Neuroscience · 2021 · 79 citations · Full text

The Amazon rain forest plant Uncaria tomentosa (cat’s claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles

Alan D. Snow, Gerardo M. Castillo, Beth P. Nguyen et al. · Scientific Reports · 2019 · 68 citations · Full text

Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia/macrophages following infusion of beta-amyloid protein into rodent hippocampus

John D. Miller, Joel A. Cummings, Grace A. Maresh et al. · Glia · 1997 · 38 citations