Sylvia Scarth

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

Craig J. Smith, Sharon Hulme, Andy Vail et al. · Stroke · 2018 · 195 citations · Full text

Life Sciences, Immunology, Pharmacotherapy +17

Reduction of inflammation after administration of interleukin-1 receptor antagonist following aneurysmal subarachnoid hemorrhage: results of the Subcutaneous Interleukin-1Ra in SAH (SCIL-SAH) study

James Galea, Kayode Ogungbenro, Sharon Hulme et al. · Journal of neurosurgery · 2017 · 128 citations · Full text

Medicine, Neurosurgery, Pharmacology +16

Interleukin-1 Receptor Antagonist Penetrates Human Brain at Experimentally Therapeutic Concentrations

Simon Clark, Catherine McMahon, Iva Gueorguieva et al. · Journal of Cerebral Blood Flow & Metabolism · 2007 · 123 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Intravenous Anakinra can Achieve Experimentally Effective Concentrations in the Central Nervous System within a Therapeutic Time Window: Results of a Dose-Ranging Study

James Galea, Kayode Ogungbenro, Sharon Hulme et al. · Journal of Cerebral Blood Flow & Metabolism · 2010 · 116 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

Clinical outcome following acute ischaemic stroke relates to both activation and autoregulatory inhibition of cytokine production

Hedley Emsley, C Gavin, Rachel Georgiou et al. · BMC Neurology · 2007 · 93 citations · Full text

Life Sciences, Immunology, Neurology +17