Autophagy maintains the metabolism and function of young and old stem cells

Theodore Ho, Matthew R. Warr, Emmalee R. Adelman, +5

Nature

Cell AutophagyMitophagyDevelopmental BiologyOld Stem CellsMedicine +7

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Dena S. Leeman, Katja Hebestreit, Tyson J. Ruetz, +13

Science

Developmental BiologyMedicineAdult Stem CellAutophagyQuiescent Stem Cells +9

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

Xueya Zhou, Pamela Feliciano, Chang Shu, +418

Nature Genetics

Cardiogenic control of affective behavioural state

Brian Hsueh, Ritchie Chen, YoungJu Jo, +24

Nature

Large-scale targeted sequencing identifies risk genes for neurodevelopmental disorders

Tianyun Wang, Kendra Hoekzema, Davide Vecchio, +232

Nature Communications

GeneticsMost GenesDisease Gene IdentificationGenomicsNdd Cases +17

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing

Carl A. Mitchell, Evgenia Verovskaya, Fernando J. Calero‐Nieto, +12

Nature Cell Biology

InflammationCytokineAutoimmune DiseaseImmunologyHematology +11

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Theodore Ho, Paul V. Dellorusso, Evgenia Verovskaya, +11

The Journal of Experimental Medicine

Cell TherapyAnti-agingAgingSystemic Rejuvenation InterventionsImmunology +19

Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders

Tianyun Wang, Chang N. Kim, Trygve E. Bakken, +169

Proceedings of the National Academy of Sciences

Autophagy counters inflammation-driven glycolytic impairment in aging hematopoietic stem cells

Paul V. Dellorusso, Melissa Proven, Fernando J. Calero‐Nieto, +13

Cell stem cell

InflammationCell AutophagyMitophagyAutoimmune DiseaseStem Cell Mobilization +9

Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis

Jasmine C. Wong, Kelley Weinfurtner, Maria del pilar Alzamora, +13

eLife

Hematological MalignancyChromatinChromosome 7Q22Mds PathogenesisHuman 7Q22 +13