Gwen Nichols

Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study

Isabelle Ray‐Coquard, Jean‐Yves Blay, Antoîne Italiano et al. · The Lancet Oncology · 2012 · 553 citations

Mdm2 Antagonist Rg7112, Medicine, Pharmacology +9

Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia

Michael Andreeff, Kevin R. Kelly, Karen Yee et al. · Clinical Cancer Research · 2015 · 344 citations · Full text

Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

Rongqing Pan, Vivian Ruvolo, Hong Mu et al. · Cancer Cell · 2017 · 299 citations · Full text

Hematological Malignancy, Medicine, Mixed-phenotype Acute Leukemia +8

Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients

S K Chai, Gwen Nichols, Paul B. Rothman · The Journal of Immunology · 1997 · 277 citations · Full text

Differentiation of immortal cells inhibits telomerase activity.

H W Sharma, J A Sokoloski, J R Perez et al. · Proceedings of the National Academy of Sciences · 1995 · 270 citations · Full text

Terminal Differentiation, Lineage Plasticity, Developmental Biology +14