Discovery of the First Non-Peptide Full Agonists for the Human Bradykinin B₂Receptor Incorporating 4-(2-Picolyloxy)quinoline and 1-(2-Picolyl)benzimidazole Frameworks

Yuki Sawada, Hiroshi Kayakiri, Yoshito Abe, +7

Journal of Medicinal Chemistry

The identification of an orally active, nonpeptide bradykinin B₂ receptor antagonist, FR173657

Masayuki Asano, Noriaki Inamura, Chie Hatori, +11

British Journal of Pharmacology

A Novel Class of Orally Active Non-Peptide Bradykinin B₂ Receptor Antagonists. 1. Construction of the Basic Framework

Yoshito Abe, Hiroshi Kayakiri, Shigeki Satoh, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryNew SeriesChemical BiologyPharmaceutical ChemistryMolecular Pharmacology +16

A Novel Class of Orally Active Non-Peptide Bradykinin B₂ Receptor Antagonists. 3. Discovering Bioisosteres of the Imidazo[1,2-<i>a</i>]pyridine Moiety

Yoshito Abe, Hiroshi Kayakiri, Shigeki Satoh, +9

Journal of Medicinal Chemistry

Combinatorial ChemistryActive Non-peptide BradykininPeptide ScienceChemical BiologyPharmaceutical Chemistry +14

A Novel Class of Orally Active Non-Peptide Bradykinin B₂ Receptor Antagonists. 4. Discovery of Novel Frameworks Mimicking the Active Conformation

Yoshito Abe, Hiroshi Kayakiri, Shigeki Satoh, +9

Journal of Medicinal Chemistry

Extensive Chemical ModificationChemical BiologyPharmaceutical ChemistryMolecular PharmacologyMedicinal Chemistry +15

Nonpeptide Mimic of Bradykinin with Long-Acting Properties at the Bradykinin B2 Receptor

Ichiro Aramori, Junko Zenkoh, Noriyuki Morikawa, +14

Molecular Pharmacology

A New Series of Highly Potent Non-Peptide Bradykinin B₂ Receptor Antagonists Incorporating the 4-Heteroarylquinoline Framework. Improvement of Aqueous Solubility and New Insights into Species Difference

Yuki Sawada, Hiroshi Kayakiri, Yoshito Abe, +9

Journal of Medicinal Chemistry

ImmunologyReceptor AntagonistsPeptide SciencePharmacotherapyNew Series +19

Effects of a nonpeptide bradykinin B₂ receptor antagonist, FR167344, on different <i>in vivo</i> animal models of inflammation

Masayuki Asano, Chie Hatori, Noriaki Inamura, +4

British Journal of Pharmacology

Carrageenin-induced Paw OedemaImmunologyImmune RegulationPharmacotherapyExperimental Pharmacology +17

A Novel Class of Orally Active Non-Peptide Bradykinin B₂ Receptor Antagonists. 2. Overcoming the Species Difference between Guinea Pig and Man

Yoshito Abe, Hiroshi Kayakiri, Shigeki Satoh, +8

Journal of Medicinal Chemistry

Active Non-peptide BradykininPharmacotherapyMolecular PharmacologyMedicinal ChemistryB2 Receptor Antagonists +16

Pharmacological characterization of a nonpeptide bradykinin B₂ receptor antagonist, FR165649, and agonist, FR190997

Masayuki Asano, Chie Hatori, Hiroe Sawai, +10

British Journal of Pharmacology